About Sinequan
Sinequan
Pharmacological action:
Antidepressant (tricyclic antidepressant) is a secondary from dybenzoxazine. Sinequan provides antidepressant, anxiolytic (antipanic), slight pain reliever (central genesis), antiulcer, antipruritic effects. Sinequan has strong peripheral and central anticholinergic effects caused by high affinity to M-cholinergic receptors and alpha-adrenoblocking effect. Sinequan has antiarrhythmic qualities like other pharmaceutics of 1a subgroup, like quinidin used in therapeutic doses, the drug slows down the ventricular conduction (in case of overdose it can cause hard intraventricular block). The mechanism of antidepressant is connected with the densification noradrenalin in synapsis and/or serotonin in central nervous system (decrerase of their reabsorption). The uptaking of these neurotransmitters is possible because of the inhibition and reuptaking by interseptiums of presynaptic neyrons.
Taking Sinequan it is possible to decrease the functional activity of beta-adreno-seratonin receptiors of cerebrum, normalize adrenergic and serotonin transmittance, rebalance of these systems, that are broken during depression. Sinequan helps to decrease psychic tension during depression, and also agitation and symptoms of depression. The mechanism of antiulcer effect happens because of the blocking of H2 – histamine receptors in stomach delomophous cells and also causes sedative and M-cholinergic effects (in case of gastric ulcer and dodecadactyon, it releives pain, helps healing ulcer). The effectivity of the uroclepsia is caused because of the anticholinergic activity. Sinequan causes central analgesic effect, that might be referred to monoamines concentration in central nervous system, especially serotonina and influence on endogenic opiod systems. The drug’s effect is not absolutely clear during bulemia treatment (it may be similar to the effect received from depression treatment). The most clear effect is possible to say when patients who suffer from bulimia, and those patients who do not suffer from depression and without are treated with this drug. During the treatment the bulimia disease can be descreased but not the symptoms of depression. During general anethesia this drug lowers arterial tension and temperature of the body. It does not inhibit monoamin oxidase. Sinequan provides analgesic effect, that can be caused because of the changes of monoamines concentration in the central nervous system, especially serotonin and influence endogenic opiod systems. The mechanism of sedative action is connected with the lowering the speed of excitement locus ceruleus by the way of regulation the following functions alpha 2 and beta-andrenoreceptors and circulation of noradrenaline. Sinequan improves mood, eliminates depression, apathy, melancholy, condition of internal tension and fear. Sinequan provides therapeutic effect in case of autonomic disorders of neurotic nature. First, the sedative action appears and the necessary antidepressant effect develops in 2-3 weeks of treatment.
Indications:
Depression (including involutional depression, mania co-depressive psychosis), anxiety (neuroses, alcoholism, organic disesaes of central nervous system, psychosis), fear, excitement, hypochondria. Panic disorders. Sleep disturbance of neurotic genesis. Pretreatment before endoscopy etc., diagnostic procedure process wihtout general anaesthesia, (intramuscular injection). Gastric ulcer and dodecadactyon, dumping syndrome, premenstrual tension, neurogenic pains (chronic pain that oncological patents usually have, browache, rheumatismal diseases, no typical face pains, postherpetic neuralgia, posttraumatic neuropathy, diabetic and etc., peripheric neuropathy), headache, browache (preventive care), skin itching happens at essential cold urticaria. Sinequan will help you if you have any of the enumarted symptoms, buy Sinequan.
